Base on the fundamental principles of life sciences and engineering, we develop biological substitutes to restore, maintain and improve tissue functions. Research of this field focuses on the following directions: the fundamental and clinical problems in the repair and regeneration of central nervous system, such as brain and spinal cord; the effect of microenvironmental factors, such as the extracellular matrix protein components, geometric properties and mechanical properties on stem cell behavior, and the regeneration of skeleton muscle and the molecular mechanism; using the micro-patterning and micro-bioreactor technology to study the intrinsic mechanism of vascular diseases such as atherosclerosis, especially focusing on the regulation of endothelial cell function by the direction and pattern of blood flow; development and application of 3D bio-printing; molecular modeling of nano-biointerfaces and nano-technology for single-cell analysis.
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